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Efficacy of vitamin D3-fortified-yogurt drink on anthropometric, metabolic, inflammatory and oxidative stress biomarkers according to vitamin D receptor gene polymorphisms in type 2 diabetic patients: a study protocol for a randomized controlled clinical trial
Sakineh Shab-Bidar, Tirang R Neyestani, Abolghassem Djazayery
BMC Endocrine Disorders , 2011, DOI: 10.1186/1472-6823-11-12
Abstract: This study comprises two parts: (i) a case-control study; and (ii) an intervention trial. In the first part, VDR polymorphisms (Taq1, FokI, Apa1, Bsm1, and Cdx2) are determined in 350 T2DM patients and 350 non-diabetic subjects. In the second part, the possible effects of daily intake of two servings of vitamin D3-fortified yogurt drink (FYD; 500 IU vitamin D/250 mL) on some selected metabolic (including insulin resistance), inflammatory and oxidative stress biomarkers in 135 T2DM patients are assessed. To relate the resulted changes in the biomarkers to vitamin D replenishment, another group of diabetic patients (n = 45) are also included in the study who receive 2 servings of plain yogurt drink (PYD) a day. The primary outcome is serum level of 25(OH) D, which it is expected to be elevated only in FYD group. Secondary outcomes include improvements in glycemic, metabolic, inflammatory and oxidative stress biomarkers in FYD group compared to PYD group. Three VDR FokI polymorphisms are determined only in FYD group followed by comparison of changes in the biomarkers among these genotypic variants.The present study, at least in part, elucidates the discrepancies in the results of different vitamin D-diabetes studies pertaining to the genetic variations of the population. If VDR polymorphisms are found to influence the response to our intervention, then knowing distribution of VDR polymorphisms in both diabetic and non-diabetic populations can give a picture of the proportion of the community in whom up to 1000 IU/d vitamin D may not be effective enough to improve insulin resistance and related morbidities. Therefore, they should ideally receive further nutritional support according to their genotype.ClinicalTrials.gov: NCT01236846Type 2 diabetes mellitus (T2DM) is a global epidemic costly condition [1]. Individuals with diabetes sustain reduction in quality of life, and high prevalence of mortality [2].Development of T2DM is determined by the interactions of genetic an
Effects of Eicosapentaenoic Acid and Vitamin E on the Plasma Levels of Antioxidant Vitamins and Inflammatory Markers, and on Erythrocyte Antioxidant Enzyme Activities, in Male Basketball Players
Ghiasvand Reza,Djalali Mahmoud,Djazayery Seyed Abolghassem,Keshavarz Seyed Ali
Acta Medica Iranica , 2009,
Abstract: Strenuous aerobic exercise is associated with oxidative stress and tissue damage. Therefore, we have investigated the effects of exercise and eicosapentaenoic acid supplementation, with or without vitamin E, on the plasma levels of vitamin C, E and A, IL-6, and glutathione peroxidase activity in basketball players. Thirty four male basketball players, enrolled in the study. Subjects received 2g EPA and/or 400 IU vitamin E or placebo depending on their groups. For 6 weeks, eight subjects took a daily EPA sup-plement together with vitamin E (group 1), nine received an EPA supplement together with placebo (group 2), nine were administered placebo along with vitamin E (group 3), and finally, eight subjects received placebo alone (group 4). As compared with group 4 (placebo), there were significant increases in vitamins C, E, and A in groups 1 and 3, but significant decreases in these parameters in group2 (P < 0.01). In addition, there were significant decreases in IL-6 in groups 1 and 3 (P < 0.01), whereas there were significant increases in glutathione peroxidase in groups1 and 3 (P < 0.01).There were significant differences in vitamin C between groups 3 and 4 (P < 0.05), and in vitamin E between groups 1 and 2, and groups 2 and 3 (P < 0.01), and in vitamin A between groups 1 and 2 (P < 0.05), and groups 1 and 4, 2 and 3, and 3 and 4 (P < 0.01), and in IL-6 between groups1 and 2 (P < 0.05), groups 1 and 3 (P < 0.01), 2 and 3 (P < 0.01), 2 and 4 (P < 0.01), and 3 and 4 (P < 0.05).
Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial
Sakineh Shab-Bidar, Tirang R Neyestani, Abolghassem Djazayery, Mohammad-Reza Eshraghian, Anahita Houshiarrad, A'azam Gharavi, Ali Kalayi, Nastaran Shariatzadeh, Malihe Zahedirad, Niloufar Khalaji, Homa Haidari
BMC Medicine , 2011, DOI: 10.1186/1741-7015-9-125
Abstract: Subjects with T2D were randomly allocated to one of the two groups to receive either plain yogurt drink (PYD; containing 170 mg calcium and no vitamin D/250 mL, n1 = 50) or vitamin D3-fortified yogurt drink (FYD; containing 170 mg calcium and 500 IU/250 mL, n2 = 50) twice a day for 12 weeks. Anthropometric measures, glycemic status, lipid profile, body fat mass (FM) and endothelial biomarkers including serum endothelin-1, E-selectin and matrix metalloproteinase (MMP)-9 were evaluated at the beginning and after the 12-week intervention period.The intervention resulted in a significant improvement in fasting glucose, the Quantitative Insulin Check Index (QUICKI), glycated hemoglobin (HbA1c), triacylglycerols, high-density lipoprotein cholesterol (HDL-C), endothelin-1, E-selectin and MMP-9 in FYD compared to PYD (P < 0.05, for all). Interestingly, difference in changes of endothelin-1, E-selectin and MMP-9 concentrations in FYD compared to PYD (-0.35 ± 0.63 versus -0.03 ± 0.55, P = 0.028; -3.8 ± 7.3 versus 0.95 ± 8.3, P = 0.003 and -2.3 ± 3.7 versus 0.44 ± 7.1 ng/mL, respectively, P < 0.05 for all), even after controlling for changes of QUICKI, FM and waist circumference, remained significant for endothelin-1 and MMP-9 (P = 0.009 and P = 0.005, respectively) but disappeared for E-selectin (P = 0.092). On the contrary, after controlling for serum 25(OH)D, the differences disappeared for endothelin-1(P = 0.066) and MMP-9 (P = 0.277) but still remained significant for E-selectin (P = 0.011).Ameliorated vitamin D status was accompanied by improved glycemic status, lipid profile and endothelial biomarkers in T2D subjects. Our findings suggest both direct and indirect ameliorating effects of vitamin D on the endothelial biomarkers.ClinicalTrials.gov: NCT01236846The prevalence of type 2 diabetes (T2D) is increasing worldwide, including Iran [1]. It has been shown that diabetes is accompanied by remarkably greater risk for cardiovascular disease (CVD). Accounting for more than
Optimal Design of Adaptive Laminated Beam Using Layerwise Finite Element
Abolghassem Zabihollah,Shahin Zareie
Journal of Sensors , 2011, DOI: 10.1155/2011/240341
Abstract: First, an efficient and accurate finite element model for smart composite beams is presented. The developed model is based on layerwise theory and includes the electromechanical coupling effects. Then, an efficient design optimization algorithm is developed which combines the layerwise finite element analysis model for the smart laminated beam, sensitivity analysis based on analytical gradients and sequential quadratic programming (SQP). Optimal size/location of sensors/actuators is determined for dynamic displacement measurement purposes and for vibration control applications. For static and eigenvalue problems, the objective is to minimize the mass of the beam under various constraints including interlaminar stresses, displacements, and frequencies. For transient vibration problems, the objective is the minimization of the actuation control effort to suppress the vibration in a controlled manner. Illustrative examples are provided to validate the formulation and to demonstrate the capabilities of the present methodology. 1. Introduction Laminated composite structures with sensing and actuation capabilities so called as smart laminated structures potentially have numerous applications in modern industries including aerospace and automotive industries. Piezoelectric materials are the most appropriate sensing/actuating elements utilized in smart laminated structures. These novel smart structures combine the superior mechanical properties of conventional composite materials and incorporate the additional inherent capability of piezoelectric layers to sense and adapt their static and dynamic response. Due to the presence of large number of material and geometrical parameters as well as loading conditions, the determination of the optimal design of the system becomes a crucial issue in smart laminated structures. The conventional design methodology leads to very long and expensive procedures which sometimes make the design infeasible, thus requiring a robust design optimization algorithm. Design optimization of smart isotropic structures has been tackled for variety of purposes and objectives such as the determination of optimal location of actuators/sensors for vibration control [1–3], optimal sensor location for vibration measurements [4], and optimal location of actuator for shape control applications [5–7]. However, design optimization of smart laminated structures still is in the preliminary level, and many issues need to be explored, including structural modeling and functions gradients, in order to come up with a robust optimization algorithm.
Developing a Model for the Estimation of Mean and Maximum Daily Discharges Using Physiographic Parameters for Atrak Watershed
Davar Khalili,Abolghassem Yousefi
Journal of Science and Technology of Agriculture and Natural Resources , 1998,
Abstract: Physiographic characteristics of Atrak Watershed described by a number of parameters were used in regression models to estimate maximum daily discharges. These parameters were sub-watershed area, main waterway length, mean waterway slope, mean watershed elevation and mean watershed slope. Based on the results of correlation between the above parameters and their suitability for discharge estimation, three regression models were developed for further analysis. Model 1 applied area as the independent variable to estimate maximum daily discharge. In model 2 area and mean watershed elevation were the independent variables. Model 3 used area and mean waterway slope as the independent variables. Even though the results of testing did identified all three models as appropriate for application, further testing selected model 1 as the most appropriate. Recommendations were made for model application to similar watersheds lacking the necessary data.
THE INFLUENCE OF AVICENNA's SCHOOL OF MEDICINE ON WESTERN MEDICINE
ABOLGHASSEM PAKDMAN,MOHAMMAD REZA GHAFFARI
Acta Medica Iranica , 1984,
Abstract:
Determination of Dietary Status as a Public Health Problem among Rural Women
F. Ansari,M. Sedehi Esfehani,A. Djazayery
Pakistan Journal of Nutrition , 2008,
Abstract: Energy, protein and iron intakes and status were investigated in 471 married women, 20-56 years old, selected by 2-stage random sampling, in rural areas in Islamic Republic of Iran. Pre-tested 24-hour dietary recall questionnaire was used to get data on nutrition intakes. Although average total iron intake was acceptable, only 6.4% of women derived at least 4% of their total intake from animal iron. Average energy and protein intakes were inadequate. Fining of this study showed that this group with medium-to-low socioeconomic status should receive particular attention in national health and nutrition planning.
Preparation and Characterization of Albumin Microspheres Encapsulated with Propranolol HCl
Sayyed Abolghassem Sajadi Tabassi,Naheed Razavi
DARU : Journal of Pharmaceutical Sciences , 2003,
Abstract: Albumin microspheres (AMS) have found many applications in the diagnosis and treatment in recent years and more than 100 diagnostic agents and drugs have been incorporated into AMS. In the present study Bovine Serum Albumin (BSA) based microspheres bearing propranolol hydrochloride were prepared by an emulsion-internal phase stabilization technique. The prepared microspheres were studied for particle size distribution, drug loading, release characteristics, bioadhesion and in-vitro controlled diffusion across the rat intestine. The microspheres had mean diameters between 1-25 mm of which more than 50 percent were below 5 mm. The encapsulated drug was found to be about 9% w/w of that initially added to microspheres and the superficial drug was 25% of the total amount of the encapsulated drug. Also AMS were noted to possess good bioadhesion in such a way that about 70% of microspheres remained adherent on the surface mucosa of rat jejunum.The drug release from albumin microspheres was mainly controlled by diffusion and showed a biphasic pattern with a high initial release (burst effect), followed by a more gradual terminal release. The total amount of drug released from microspheres after 12h was 70%. In vitro experiments on the rat intestinal segments revealed that the microspheres could effectively pass their content through intestinal membrane.
Synthesis and characterization of a novel non-enzymatic glucose biosensor based on polyaniline/zinc oxide/multi-walled carbon nanotube ternary nanocomposite
Dolati, Abolghassem,Mohajeri, Soha,Yazdanbakhsh, Khashayar
- , 2019, DOI: 10.5599/jese.666
Abstract: Sa？etak Novel polyaniline/zinc oxide/multi-walled carbon nanotube (PANI/ZnO/MWCNT) ternary nanocomposite was fabricated as a non-enzymatic glucose biosensor. Thermal chemical vapor deposition (CVD) process was employed to synthesize vertically aligned MWCNTs on stainless steel substrates coated by Co catalyst nanoparticles. In order to fabricate sensitive and reliable MWCNT-based biosensors, nanotubes density and alignment were adjusted by varying the CVD reaction time and cobalt sulfate concentration. The fabricated nanotubes were modified by ZnO particles through the potentiostatic electrodeposition technique. Optimal electrodeposition potential, electrodeposition time, and electrolyte concentration values were determined. The optimized ZnO/MWCNT nanocomposite was reinforced by polyaniline (PANI) nanofibers through the potential cycling technique, and the morphology, elemental composition, and phase structure of the fabricated nanocomposites were characterized by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD), respectively. The sensing mechanism of the PANI/ZnO/MWCNT electrode for the electrochemical detection of glucose was investigated, and the limit of detection and sensitivity values of the designed sensor were determined. The fast response time of the ternary nanocomposite-based sensor as well as its satisfactory stability and reproducibility, makes it a promising candidate for non-enzymatic detection of glucose in biomedical, environmental, and industrial applications
The template-assisted electrodeposition of platinum nanowires for catalytic applications
Daryan, Sahar Hashemi,Dolati, Abolghassem,Mohajeri, Soha
- , 2018, DOI: 10.5599/jese.495
Abstract: Sa？etak Template-assisted electrodeposition technique was applied to synthesize platinum nanowires (Pt NWs) on polycarbonate templates (PCT) with pore diameters of 15, 50, and 100 nm for catalytic applications. Influences of sulfuric acid added to the electrolyte, different potential scanning rates and different pore diameters of templates on the electrodeposition process of Pt NWs were investigated by electrochemical techniques, including voltammetry and chronoamperometry methods. It was confirmed that at lower scan rates and in acidic solutions, electrodeposition of platinum on templates with larger pores is controlled by diffusion. The potential range for deposition of Pt NWs was determined and the potentiostatic technique was utilized by applying various potentials of different durations to fabricate the NWs. The morphological characteristics of Pt NWs were examined using the scanning electron microscopy (SEM). It was shown that the growth of Pt NWs on PCT 50 nm followed a pine-tree pattern, while the Pt NWs grew spherically on PCT 100 nm. The uniform and compact shape of Pt NWs was verified by the transmission electron microscopy (TEM). The catalytic activities of the prepared Pt NWs with the same exchanged charge density for hydrogen adsorption/desorption and methanol oxidation reactions were determined by the cyclic voltammetry (CV) testing, and the superior electrocatalytic performance was detected for Pt NWs prepared on PCT 50 nm. This enhanced catalytic activity was attributed to the higher surface-to-volume ratio, larger electrochemical active surface area and higher density of exposed active sites accessible on the pine-tree morphology of these Pt NWs compared to the spherical structure of Pt NWs fabricated on PCT 100 nm. This makes Pt NWs prepared on PCT 50 nm to be a promising catalyst for direct methanol fuel cells (DMFCs)
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